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Article

Schizophrenia-related Xpo7 haploinsufficiency leads to behavioral and nuclear transport pathologies.

EMBO reports - 1 Feb 2025

Toyoda Saori, Kikuchi Masataka, Abe Yoshifumi, Tashiro Kyosei, Handa Takehisa, Katayama Shingo, Motokawa Yukiko, Tanaka Kenji F, Takahashi Hidehiko, Shiwaku Hiroki

Abstract excerpt

Recent genetic studies by the Schizophrenia Exome Sequencing Meta-Analysis (SCHEMA) consortium have identified that protein-truncating variants of exportin 7 (XPO7) can increase the risk of schizophrenia (odds ratio, 28.1). Here we show that mice with Xpo7 haploinsufficiency (Xpo7+/- mice) present with cognitive and social behavioral impairments. Through proteome analysis using immunoprecipitation and frontal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39774335
DOI: 10.1038/s44319-024-00362-9
PMCID: PMC11850608

Genes

XPO7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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