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Article

A 3D Tissue Model of Traumatic Brain Injury with Excitotoxicity That Is Inhibited by Chronic Exposure to Gabapentinoids.

Biomolecules - 17 Aug 2020

Rouleau Nicolas, Bonzanni Mattia, Erndt-Marino Joshua D, Sievert Katja, Ramirez Camila G, Rusk William, Levin Michael, Kaplan David L

Abstract excerpt

Injury progression associated with cerebral laceration is insidious. Following the initial trauma, brain tissues become hyperexcitable, begetting further damage that compounds the initial impact over time. Clinicians have adopted several strategies to mitigate the effects of secondary brain injury; however, higher throughput screening tools with modular flexibility are needed to expedite mechanistic studies and...

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Identifiers

PMID: 32824600
DOI: 10.3390/biom10081196
PMCID: PMC7463727

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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