Article
Polymorphisms within Genes Coding for IL-17A and F and Their Receptor as Clinical Hallmarks in Ankylosing Spondylitis.
Mediators of inflammation - 1 Jan 2021
Wielińska Joanna, Świerkot Jerzy, Kolossa Katarzyna, Bugaj Bartosz, Chaszczewska-Markowska Monika, Jeka Sławomir, Bogunia-Kubik Katarzyna
Abstract excerpt
IL-17A and IL-17F together with their coreceptor (IL-17RA/RC) were reported to play a significant role in the pathogenesis of spondyloarthritis. The group of axial spondyloarthritis comprises ankylosing spondylitis (AS), a rheumatic disease characterized by chronic inflammation of the joints in the spine. This study is aimed at investigating IL-17A, IL-17F, IL-17RA, and IL-17RC polymorphisms as potential...
Topics
- Alleles
- Genetic Predisposition to Disease
- Humans
- Interleukin-17
- Polymorphism, Genetic
- Polymorphism, Single Nucleotide
- Receptors, Interleukin-7
- Spondylitis, Ankylosing
- Tumor Necrosis Factor Inhibitors