Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IGFBP6 orchestrates antiinfective immune collapse in murine sepsis via prohibitin-2–mediated immunosuppression

2 Sept 2025

Abstract excerpt

The persistent challenge of sepsis-related mortality underscores the necessity for deeper insights. Our multicenter, cross-age cohort study identified insulin-like growth factor binding protein 6 (IGFBP6) as a critical regulator in sepsis diagnosis, prognosis, and mortality risk evaluation. Mechanistically, IGFBP6 engages in IGF-independent binding to prohibitin2 (PHB2) on epithelial cells, driving PHB2 tyrosine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Hormones and Disorders
Share to Inflammation biomarkers and pathways
Share to Sepsis Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40892465
DOI: 10.1172/jci184721

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IGFBP6 orchestrates antiinfective immune collapse in murine sepsis via prohibitin-2–mediated immunosuppressionPMID 40892465Read ↗

Therapeutic Targets for Sepsis: Multicenter Proteome-Wide Analyses and Experimental ValidationSemantic proximity Read ↗

Investigating immune dysregulation and hub genes in septic cardiomyopathy developmentSemantic proximity Read ↗

Transcriptional responses in different mouse models of septic liver injury differ from those in patients with septic liver injurySemantic proximity Read ↗

Malat1 regulates PMN-MDSC expansion and immunosuppression through p-STAT3 ubiquitination in sepsisSemantic proximity Read ↗

Exploring the prognostic necroptosis-related genes and underlying mechanism in sepsis using bioinformaticsSemantic proximity Read ↗

Immunogenomic Landscape of B cells in Patients with Septic ShockSemantic proximity Read ↗

IL-1R2 as a Precision Therapeutic Target in Sepsis: Molecular Insights into Immune RegulationSemantic proximity Read ↗

CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome Through Mediating Macrophage Polarization via the miR-138-5p/EZH2 AxisSemantic proximity Read ↗

LncRNA NEAT1 exacerbates sepsis-induced acute lung injury via targeting miR-26a-5p/ROCK1 axisSemantic proximity Read ↗

Extracellular vesicle-packaged GBP2 from macrophages aggravates sepsis-induced acute lung injury by promoting ferroptosis in pulmonary vascular endothelial cellsSemantic proximity Read ↗

Analysis of novel plasma protein biomarkers in sepsis using DIA mass spectrometrySemantic proximity Read ↗

Integrated Bioinformatics Analysis Identifies and Validates Novel Cellular Senescence-Associated Genes in Sepsis and Sepsis-Induced ARDSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.