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Article

COPD subtypes identified by network-based clustering of blood gene expression.

Genomics - 1 Mar 2016

Chang Yale, Glass Kimberly, Liu Yang-Yu, Silverman Edwin K, Crapo James D, Tal-Singer Ruth, Bowler Russ, Dy Jennifer, Cho Michael, Castaldi Peter

Abstract excerpt

One of the most common smoking-related diseases, chronic obstructive pulmonary disease (COPD), results from a dysregulated, multi-tissue inflammatory response to cigarette smoke. We hypothesized that systemic inflammatory signals in genome-wide blood gene expression can identify clinically important COPD-related disease subtypes, and we leveraged pre-existing gene interaction networks to guide unsupervised...

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Identifiers

PMID: 26773458
DOI: 10.1016/j.ygeno.2016.01.004
PMCID: PMC4761317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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