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Article

Distinct physiological, transcriptomic, and imaging characteristics of asthma-COPD overlap compared to asthma and COPD in smokers.

EBioMedicine - 1 Dec 2024

Fangal Vrushali D, Saferali Aabida, Castaldi Peter J, Hersh Craig P, Weiss Scott T

Abstract excerpt

BACKGROUND: The clinical and pathological features of asthma and chronic obstructive pulmonary disease (COPD) can converge in smokers and elderly individuals as asthma-COPD overlap (ACO). This overlap challenges the diagnosis and treatment of the distinct aetiologies underlying these conditions. METHODS: We analysed 2453 smokers (≥10 pack-years), aged 45-80 years, from the Genetic Epidemiology of COPD (COPDGene)...

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Identifiers

PMID: 39580967
DOI: 10.1016/j.ebiom.2024.105453
PMCID: PMC11621799

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