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Article

PADI4 Polymorphisms Confer Risk of Anti-CCP-Positive Rheumatoid Arthritis in Synergy With HLA-DRB1*04 and Smoking.

Frontiers in immunology - 1 Jan 2021

Massarenti Laura, Enevold Christian, Damgaard Dres, Ødum Niels, Garred Peter, Frisch Morten, Shelef Miriam A, Jacobsen Søren, Nielsen Claus Henrik

Abstract excerpt

Peptidylarginine deiminases (PADs) catalyze citrullination, a post-translational modification playing a pathogenic role in anti-citrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA). The interplay between single nucleotide polymorphisms (SNPs) in the PADI genes and known risk factors for ACPA-positive RA, including smoking, HLA-DR4 and -1, and the PTPN22 R620W polymorphism, was investigated. We...

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Identifiers

PMID: 34733271
DOI: 10.3389/fimmu.2021.707690
PMCID: PMC8558474

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