Article
Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study.
Arthritis research & therapy - 1 Jan 2010
Bang So-Young, Han Tae-Un, Choi Chan-Bum, Sung Yoon-Kyoung, Bae Sang-Cheol, Kang Changwon
Abstract excerpt
INTRODUCTION: Anti-cyclic citrullinated peptide autoantibodies (anti-CCP) are the most specific serologic marker for rheumatoid arthritis (RA). Genetic polymorphisms in a citrullinating (or deiminating) enzyme, peptidyl arginine deiminase type IV (PADI4) have been reproducibly associated with RA susceptibility in several populations. We investigated whether PADI4 polymorphisms contribute to anti-CCP-negative as...
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