Article
Germline deletion reveals a non-essential role of the atypical MAPK6/ERK3
2018-11-10
Abstract excerpt
MAPK6/ERK3 is an atypical member of the MAPKs. An essential role has been suggested by the perinatal lethal phenotype of ERK3 knockout mice carrying a lacZ insertion in exon 2 due to pulmonary disfunction and by defects in function, activation and positive selection of T cells. To study the role of ERK3 in vivo , we generated mice carrying a conditional Erk3 allele with exon3 flanked by LoxP sites. Loss of ERK3...
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Identifiers and source
- Literature Corpus work
- 2c6c0955-d4d6-5e0c-a673-cd4c79d6f435
- DOI
- 10.1101/467597