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Article

A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.

Cell reports - 5 Jan 2021

Sun Hong, Huang Yu, Mei Shan, Xu Fengwen, Liu Xiaoman, Zhao Fei, Yin Lijuan, Zhang Di, Wei Liang, Wu Chao, Ma Shichao, Wang Jianwei, Cen Shan, Liang Chen, Hu Siqi, Guo Fei

Abstract excerpt

The cyclic GMP-AMP (cGAMP) synthase (cGAS) is a key DNA sensor that initiates STING-dependent signaling to produce type I interferons through synthesizing the secondary messenger 2'3'-cGAMP. In this study, we confirm previous studies showing that cGAS is located both in the cytoplasm and in the nucleus. Nuclear accumulation is observed when leptomycin B is used to block the exportin, CRM1 protein. As a result,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33406424
DOI: 10.1016/j.celrep.2020.108586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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