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Article

Mechanism of the decrease in catalytic activity of human cytochrome P450 2C9 polymorphic variants investigated by computational analysis.

Journal of computational chemistry - 30 Nov 2010

Sano Eri, Li Weihua, Yuki Hitomi, Liu Xinli, Furihata Tomomi, Kobayashi Kaoru, Chiba Kan, Neya Saburo, Hoshino Tyuji

Abstract excerpt

Cytochrome P450 (CYP) is deeply involved in the metabolism of chemicals including pharmaceuticals. Therefore, polymorphisms of this enzyme have been widely studied to avoid unfavorable side effects of drugs in chemotherapy. In this work, we performed computational analysis of the mechanism of the decrease in enzymatic activity for three typical polymorphisms in CYP 2C9 species: *2, *3, and *5. Based on the...

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Identifiers

PMID: 20839301
DOI: 10.1002/jcc.21568

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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