Article
Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia.
Blood advances - 8 May 2018
Imi Tatsuya, Katagiri Takamasa, Hosomichi Kazuyoshi, Zaimoku Yoshitaka, Hoang Nguyen Viet, Nakagawa Noriharu, Tajima Atsushi, Yoshizato Tetsuichi, Ogawa Seishi, Nakao Shinji
Abstract excerpt
Clonal hematopoiesis by hematopoietic stem progenitor cells (HSPCs) that lack an HLA class I allele (HLA- HSPCs) is common in patients with acquired aplastic anemia (AA); however, it remains unknown whether the cytotoxic T lymphocyte (CTL) attack that allows for survival of HLA- HSPCs is directed at nonmutated HSPCs or HSPCs with somatic mutations or how escaped HLA- HSPC clones support sustained hematopoiesis....
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