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Article

TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafish.

RNA biology - 1 Jan 2014

Reverendo Marisa, Soares Ana R, Pereira Patrícia M, Carreto Laura, Ferreira Violeta, Gatti Evelina, Pierre Philippe, Moura Gabriela R, Santos Manuel A

Abstract excerpt

Mutations in genes that encode tRNAs, aminoacyl-tRNA syntheases, tRNA modifying enzymes and other tRNA interacting partners are associated with neuropathies, cancer, type-II diabetes and hearing loss, but how these mutations cause disease is unclear. We have hypothesized that levels of tRNA decoding error (mistranslation) that do not fully impair embryonic development can accelerate cell degeneration through...

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Identifiers

PMID: 25483040
DOI: 10.4161/rna.32199
PMCID: PMC4615818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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