Article
Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration.
Nature - 7 Sept 2006
Lee Jeong Woong, Beebe Kirk, Nangle Leslie A, Jang Jaeseon, Longo-Guess Chantal M, Cook Susan A, Davisson Muriel T, Sundberg John P, Schimmel Paul, Ackerman Susan L
Abstract excerpt
Misfolded proteins are associated with several pathological conditions including neurodegeneration. Although some of these abnormally folded proteins result from mutations in genes encoding disease-associated proteins (for example, repeat-expansion diseases), more general mechanisms that lead to misfolded proteins in neurons remain largely unknown. Here we demonstrate that low levels of mischarged transfer RNAs...
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