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14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T and myeloid immature acute leukemia

19 Apr 2021

Abstract excerpt

Acute leukemias (ALs) of ambiguous lineage are a heterogeneous group of high-risk leukemias characterized by coexpression of myeloid and lymphoid markers. In this study, we identified a distinct subgroup of immature acute leukemias characterized by a broadly variable phenotype, covering acute myeloid leukemia (AML, M0 or M1), T/myeloid mixed-phenotype acute leukemia (T/M MPAL), and early T-cell precursor acute...

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PMID: 33876209
DOI: 10.1182/blood.2020010510

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