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Article

Acute leukemia with BCL11B rearrangements: Genetic landscape, BCL11B expression, and therapeutic response.

Human pathology - 1 May 2026

Tang Guilin, Wang Sa A, Jen Wei Ying, Medeiros L Jeffrey, Wang Wei, Fang Hong, Hu Shimin, Jain Nitin, Jabbour Elias Joseph, Zou Ying S, Xu Jie

Abstract excerpt

Rearrangements involving BCL11B have emerged as important structural variants in acute leukemias with T lineage differentiation, yet their prevalence and biological significance remain incompletely defined. Using optical genome mapping (OGM), we identified BCL11B rearrangements in 25 of 2325 hematologic malignancies, restricted to T-lymphoblastic leukemia particularly early T precursor (ETP) subtype, mixed...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to Repressor Proteins

Share to Translocation, Genetic

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Source

Identifiers

PMID: 41581705
DOI: 10.1016/j.humpath.2026.106057

Genes

BCL11B
TLX3
ARID1B
CDK6
FOXF1
GRM4
LMO2
NUP98
TLX1
TNFAIP3
TRRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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