Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between human paraoxonase 2 protein and efficacy of acetylcholinesterase inhibiting drugs used against Alzheimer's disease.

PloS one - 1 Jan 2021

Parween Fauzia, Hossain Md Summon, Singh Kshetra Pal, Gupta Rinkoo Devi

Abstract excerpt

Serum Paraoxonase 2 (PON2) level is a potential biomarker owing to its association with a number of pathophysiological conditions such as atherosclerosis and cardiovascular disease. Since cholinergic deficiency is closely linked with Alzheimer's disease (AD) progression, acetylcholinesterase inhibitors (AChEIs) are the treatment of choice for patients with AD. However, there is a heterogenous response to these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Aryldialkylphosphatase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholinesterase Inhibitors

Share to Mutation

Share to Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 34714861
DOI: 10.1371/journal.pone.0258879
PMCID: PMC8555796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between human paraoxonase 2 protein and efficacy of acetylcholinesterase inhibiting drugs used against Alzheimer's disease.PMID 34714861Read ↗

Pharmacogenetics of paraoxonases: a brief review.Semantic proximity Read ↗

Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities.Semantic proximity Read ↗

Paraoxonase (PON1) polymorphism and activity as the determinants of sensitivity to organophosphates in human subjects.Semantic proximity Read ↗

Catalytic properties and distribution profiles of paraoxonase and cholinesterase phenotypes in human sera.Semantic proximity Read ↗

Human serum paraoxonase (PON1) activity in acute organophosphorous insecticide poisoning.Semantic proximity Read ↗

Paraoxonase phenotype distribution in a healthy Iranian population.Semantic proximity Read ↗

Effect of the CYP2D6 and APOE Polymorphisms on the Efficacy of Donepezil in Patients with Alzheimer's Disease: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.Semantic proximity Read ↗

Paraoxonase 1 in neurological disorders.Semantic proximity Read ↗

Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias.Semantic proximity Read ↗

Determination of paraoxonase (PON1) status requires more than genotyping.Semantic proximity Read ↗

Pharmacogenetic considerations when prescribing cholinesterase inhibitors for the treatment of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.