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Article

The Role of Inherited Pathogenic CDKN2A Variants in Susceptibility to Pancreatic Cancer.

Pancreas - 1 Sept 2021

Kimura Hirokazu, Klein Alison P, Hruban Ralph H, Roberts Nicholas J

Abstract excerpt

ABSTRACT: CDKN2A is cell cycle negative regulator, and the role of CDKN2A in the development of pancreatic ductal adenocarcinoma, which continues to be a lethal cancer, is well-established. Somatic loss of CDKN2A is considered one of the major drivers of pancreatic tumorigenesis. CDKN2A gene is one of the pancreatic cancer susceptibility gene; in addition to melanoma, pathogenic germline CDKN2A variants have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34714275
DOI: 10.1097/MPA.0000000000001888
PMCID: PMC8562885

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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