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Article

Derivation and Validation of Genome-Wide Polygenic Score for Ischemic Heart Failure.

Journal of the American Heart Association - 16 Nov 2021

Paranjpe Ishan, Tsao Noah L, De Freitas Jessica K, Judy Renae, Chaudhary Kumardeep, Forrest Iain S, Jaladanki Suraj K, Paranjpe Manish, Sharma Pranav, Glicksberg Benjamin S, Narula Jagat, Do Ron, Damrauer Scott M, Nadkarni Girish N

Abstract excerpt

Background Despite advances in cardiovascular disease and risk factor management, mortality from ischemic heart failure (HF) in patients with coronary artery disease (CAD) remains high. Given the partial role of genetics in HF and lack of reliable risk stratification tools, we developed and validated a polygenic risk score for HF in patients with CAD, which we term HF-PRS. Methods and Results Using summary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34713709
DOI: 10.1161/JAHA.121.021916
PMCID: PMC8751935

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