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Article

Frequency of FLT3 Internal Tandem Duplications in Adult Syrian Patients with Acute Myeloid Leukemia and Normal Karyotype.

Asian Pacific journal of cancer prevention : APJCP - 1 Oct 2021

Al-Arbeed Ismael F, Wafa Abdulsamad, Moassass Faten, Al-Halabi Bassel, Al-Achkar Walid, Abou-Khamis Imad

Abstract excerpt

OBJECTIVE: Activating mutations of the fms-like tyrosine kinase 3 gene (FLT3) by internal tandem duplications (ITDs) in the juxtamembrane domain (JMD) have been reported in ~30% of adult acute myeloid leukemia (AML) patients with cytogenetically normal karyotype (CN). However, FLT3/ITD mutations are frequently accompanied with leukocytosis, high percentage of blasts in bone marrow (BM), and increased the risk of...

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Identifiers

PMID: 34711001
DOI: 10.31557/APJCP.2021.22.10.3245
PMCID: PMC8858225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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