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Article

FLT3 Gene Mutation Profile and Prognosis in Adult Acute Myeloid Leukemia.

Clinical laboratory - 1 Oct 2016

Azari-Yam Aileen, Tavakkoly-Bazzaz Javad, Semnani Yousef, Davoudi-Dehaghani Elham, Ghodssi-Ghassemabadi Robabeh, Kianfar Soodeh, Saadat Ameneh, Masoudifard Mahboobeh, Yaghmaie Marjan, Alimoghaddam Kamran, Ghavamzadeh Ardeshir, Zeinali Sirous

Abstract excerpt

BACKGROUND: Internal tandem duplication (ITD) of FMS-related tyrosine kinase 3 (FLT3) gene, which occurs in exons 14 and 15, is one of the most prevalent somatic mutations in adult acute myeloid leukemia (AML) and has biological, prognostic, and therapeutic implications. The prognostic importance of codon 835 tyrosine kinase domain (TKD) mutation (exon 20), which occurs relatively frequently in adult AML, is...

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Source

Identifiers

PMID: 28164537
DOI: 10.7754/Clin.Lab.2016.160324

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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