Article
Genetically Determined Low-Density Lipoprotein Cholesterol and Risk of Subarachnoid Hemorrhage.
Annals of neurology - 1 Jan 2022
Acosta Julián N, Both Cameron P, Szejko Natalia, Leasure Audrey C, Abdelhakim Safa, Torres-Lopez Victor M, Brown Stacy C, Matouk Charles C, Gunel Murat, Sheth Kevin N, Falcone Guido J
Abstract excerpt
We evaluated whether genetically elevated low-density lipoprotein cholesterol (LDL-C) levels are associated with lower risk of intracranial aneurysms and subarachnoid hemorrhage (IA/SAH). We conducted a 2-sample Mendelian randomization (MR) study. Our primary analysis used the inverse-variance weighted method. In secondary analyses, we implemented the MR-PRESSO method, restricted our analysis to LDL-C-specific...
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