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Modifiable lifestyle factors and risk of intracranial aneurysm: A univariate and multivariate Mendelian randomisation study.

Neuroscience - 6 Feb 2025

Tan Jiacong, Zhu Huaxin, Zeng Yanyang, Li Jiawei, Zhao Yeyu, Li Meihua

Abstract excerpt

The aim of this study was to assess the potential causal relationship between lifestyle factors and intracranial aneurysms (IAs) using a two-sample Mendelian randomization (MR) approach. The study used a pooled dataset from a genome-wide association study that covered information on 24 lifestyle factors, intracranial aneurysm cases, subarachnoid hemorrhage, and unruptured aneurysms. Five MR methods were applied...

Topics

Intracranial Aneurysm
Humans
Mendelian Randomization Analysis
Life Style
Polymorphism, Single Nucleotide
Risk Factors
Genome-Wide Association Study
Genetic Predisposition to Disease
Smoking
Subarachnoid Hemorrhage

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Identifiers

PMID: 39706516
DOI: 10.1016/j.neuroscience.2024.12.034

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