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Article

Association of serum lipidomic profiles with risk of intracranial aneurysm: A Mendelian randomization study.

Journal of neurochemistry - 1 Feb 2025

Zhang Mingqin, Yang Dongyi, Wang Jiabin, Wang Dan, Xu Jin, Wang Yibo

Abstract excerpt

A two-sample Mendelian randomization (MR) analysis was utilized to assess the causal relationship between lipidomic profiles and the risk of intracranial aneurysms (IAs). Genetic variants related to lipidomic profiles (227 components) and IA [IA, aneurysmal subarachnoid hemorrhage (aSAH) only, unruptured IA (uIA) only] were obtained from published genome-wide association studies (GWASs) or the IEU Open GWAS...

Read the complete abstract on PubMed

Topics

Humans
Mendelian Randomization Analysis
Intracranial Aneurysm
Lipidomics
Genome-Wide Association Study
Lipids

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Risk Factors

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 39449543
DOI: 10.1111/jnc.16247

Provenance

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