Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage.

doi:10.1002/ana.25740

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Article

Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage.

Annals of neurology - 1 Jul 2020

Falcone Guido J, Kirsch Elayna, Acosta Julian N, Noche Rommell B, Leasure Audrey, Marini Sandro, Chung Jaeyoon, Selim Magdy, Meschia James F, Brown Devin L, Worrall Bradford B, Tirschwell David L, Jagiella Jeremiasz M, Schmidt Helena, Jimenez-Conde Jordi, Fernandez-Cadenas Israel, Lindgren Arne, Slowik Agnieszka, Gill Dipender, Holmes Michael, Phuah Chia-Ling, Petersen Nils H, Matouk Md Charles N, Gunel Murat, Sansing Lauren, Bennett Derrick, Chen Zhengming, Sun Luan L, Clarke Robert, Walters Robin G, Gill Thomas M, Biffi Alessandro, Kathiresan Sekar, Langefeld Carl D, Woo Daniel, Rosand Jonathan, Sheth Kevin N, Anderson Christopher D

Abstract excerpt

OBJECTIVE: Observational studies point to an inverse correlation between low-density lipoprotein (LDL) cholesterol levels and risk of intracerebral hemorrhage (ICH), but it remains unclear whether this association is causal. We tested the hypothesis that genetically elevated LDL is associated with reduced risk of ICH. METHODS: We constructed one polygenic risk score (PRS) per lipid trait (total cholesterol, LDL,...

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PMID: 32277781
DOI: 10.1002/ana.25740
PMCID: PMC7523882

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