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Article

Association between Molecular Genetic Markers of DNA Repair and Cell Cycle Control Genes and Response to Platinum-Based Chemotherapy in Ovarian Cancer Patients.

Bulletin of experimental biology and medicine - 1 Oct 2021

Zavarikina T M, Khokhlova S V, Tyulyandina A S, Khabas G N, Asaturova A V, Nosova Yu V, Brenner P K, Kapralova M A, Khodirev D S, Stenina M B

Abstract excerpt

We analyzed associations of polymorphic markers of DNA repair genes (XRCC1, ERCC2), cell cycle control genes (TP53, MDM2, and CDKN1A), methylation of promoter region, and mutation 5382insC of BRCA1 gene in ovarian cancer with effectiveness of platinumbased chemotherapy assessed by the median of progression-free survival time for markers of DNA repair genes and by relapse risk for all studied markers. An increase...

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Identifiers

PMID: 34709513
DOI: 10.1007/s10517-021-05310-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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