Article
DNA repair gene associated with clinical outcome of epithelial ovarian cancer treated with platinum-based chemotherapy.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013
Kang Shan, Sun Hai-Yan, Zhou Rong-Miao, Wang Na, Hu Pei, Li Yan
Abstract excerpt
OBJECTIVE: The nucleotide excision repair (NER) and base excision repair (BER) pathways, two DNA repair pathways, are related to platinum resistance in cancer treatment. In this paper, we studied the association between single nucleotide polymorphisms (SNPs) of involved genes and response to platinum-based chemotherapy in epithelial ovarian cancer. METHOD: Eight SNPs in XRCC1 (BER), XPC and XPD (NER) were...
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