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Platinum Resistance in Ovarian Cancer: Role of DNA Repair

20 Jan 2019

Abstract excerpt

Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. It is initially responsive to cisplatin and carboplatin, two DNA damaging agents used in first line therapy. However, almost invariably, patients relapse with a tumor resistant to subsequent treatment with platinum containing drugs. Several mechanisms associated with the development of acquired drug resistance have been reported. Here we...

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PMID: 30669514
DOI: 10.3390/cancers11010119

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