Article
Association of Molecular Genetic Markers of TP53, MDM2, and CDKN1A Genes with Progression-Free Survival of Patients with Ovarian Cancer after Platinum-Based Chemotherapy.
Bulletin of experimental biology and medicine - 1 Aug 2020
Zavarykina T M, Tyulyandina A S, Khokhlova S V, Khabas G N, Asaturova A V, Nosova Yu A, Brenner P K, Kapralova M A, Atkarskaya M V, Khodyrev D S, Burdennyi A M, Loginov V I, Stenina M B, Sukhikh G T
Abstract excerpt
We studied the association of polymorphic markers of cell cycle control genes (Arg72Pro of the TP53 gene, T(-410)G of the MDM2 gene, and Ser31Arg of the CDKN1A gene) in ovarian cancer and progression-free survival following platinum-based chemotherapy. Tumor tissue samples obtained from 49 patients who had undergone chemotherapy were examined. Patients received standard platinum-based chemotherapy and were...
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