Article
BRCA mutation carriers suffering from ovarian cancer as a model for treatment decision in higher lines - Place for platinum reinduction.
Journal of cancer research and therapeutics - 1 Jan 2000
Zikan Michal, Vecerova Livia, Dubova Olga, Sehnal Borek, Soukupova Jana
Abstract excerpt
Context: Ovarian carcinoma is a malignancy with the highest mortality among gynecological cancers. Mutations in BRCA1/2 genes are believed to be a favorable prognostic factor and that, in general, the biological behavior of ovarian cancer in BRCA-positive individuals differs from others. However, some clinically relevant issues (i.e., prediction of response to chemotherapy and treatment of platinum-resistant...
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