Article
[ERCC1 as a Marker of Ovarian Cancer Resistance to Platinum Drugs].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] - 1 Jan 2015
Bogush T A, Popova A S, Dudko E A, Bogush E A, Tyulyandina A S, Tyulyandin S A, Davydov M I
Abstract excerpt
The review is concerned with the crucial marker of nucleotide excision repair ERCC1 and its contribution to platinum resistance of ovarian cancer. All the variants of the laboratory and clinical ERCC1 assessment in the ovarian cancer tissue (single nucleotide polymorphisms of the ERCC1 gene, levels of mRNA or protein) are considered. Data on the prognostic and predictive value of ERCC1 as a marker of the response...
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