Article
The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.
Science translational medicine - 24 Feb 2016
Mlecnik Bernhard, Bindea Gabriela, Kirilovsky Amos, Angell Helen K, Obenauf Anna C, Tosolini Marie, Church Sarah E, Maby Pauline, Vasaturo Angela, Angelova Mihaela, Fredriksen Tessa, Mauger Stéphanie, Waldner Maximilian, Berger Anne, Speicher Michael R, Pagès Franck, Valge-Archer Viia, Galon Jérôme
Abstract excerpt
Although distant metastases account for most of the deaths in cancer patients, fundamental questions regarding mechanisms that promote or inhibit metastasis remain unanswered. We show the impact of mutations, genomic instability, lymphatic and blood vascularization, and the immune contexture of the tumor microenvironment on synchronous metastases in large cohorts of colorectal cancer patients. We observed large...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.