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A novel druggable interprotomer pocket in the capsid of rhino- and enteroviruses

11 Jun 2019

Abstract excerpt

Rhino- and enteroviruses are important human pathogens, against which no antivirals are available. The best-studied inhibitors are "capsid binders" that fit in a hydrophobic pocket of the viral capsid. Employing a new class of entero-/rhinovirus inhibitors and by means of cryo-electron microscopy (EM), followed by resistance selection and reverse genetics, we discovered a hitherto unknown druggable pocket that is...

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PMID: 31185007
DOI: 10.1371/journal.pbio.3000281

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