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Article

Within-Host Rhinovirus Evolution in Upper and Lower Respiratory Tract Highlights Capsid Variability and Mutation-Independent Compartmentalization.

The Journal of infectious diseases - 14 Feb 2024

Makhsous Negar, Goya Stephanie, Avendaño Carlos C, Rupp Jason, Kuypers Jane, Jerome Keith R, Boeckh Michael, Waghmare Alpana, Greninger Alexander L

Abstract excerpt

BACKGROUND: Rhinovirus (RV) infections can progress from the upper (URT) to lower (LRT) respiratory tract in immunocompromised individuals, causing high rates of fatal pneumonia. Little is known about how RV evolves within hosts during infection. METHODS: We sequenced RV complete genomes from 12 hematopoietic cell transplant patients with infection for up to 190 days from both URT (nasal wash, NW) and LRT...

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Identifiers

PMID: 37486790
DOI: 10.1093/infdis/jiad284
PMCID: PMC10873175

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