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Article

Impact of Hydrocortisone and of CRH Infusion on the Hypothalamus-Pituitary-Adrenocortical Axis of Septic Male Mice.

Endocrinology - 1 Jan 2022

Téblick Arno, De Bruyn Lauren, Van Oudenhove Tim, Vander Perre Sarah, Pauwels Lies, Derde Sarah, Langouche Lies, Van den Berghe Greet

Abstract excerpt

PURPOSE: Sepsis is hallmarked by high plasma cortisol/corticosterone (CORT), low adrenocorticotropic hormone (ACTH), and high pro-opiomelanocortin (POMC). While corticotropin-releasing hormone-(CRH) and arginine-vasopressin (AVP)-driven pituitary POMC expression remains active, POMC processing into ACTH becomes impaired. Low ACTH is accompanied by loss of adrenocortical structure, although steroidogenic enzymes...

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Identifiers

PMID: 34698826
DOI: 10.1210/endocr/bqab222
PMCID: PMC8599906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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