Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The unfolded protein response links tumor aneuploidy to local immune dysregulation

26 Oct 2021

Abstract excerpt

Abstract Aneuploidy is a chromosomal abnormality associated with poor prognosis in many cancer types. Here, we tested the hypothesis that the unfolded protein response (UPR) mechanistically links aneuploidy and local immune dysregulation. Using a single somatic copy number alteration (SCNA) score inclusive of whole-chromosome, chromosome arm, and focal alterations in a pan-cancer analysis of 9,375 samples in The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum Stress and Disease
Share to Pancreatic function and diabetes
Share to Phagocytosis and Immune Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34698427
DOI: 10.15252/embr.202152509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The unfolded protein response links tumor aneuploidy to local immune dysregulationPMID 34698427Read ↗

The unfolded protein response links tumor aneuploidy to local immune dysregulationSemantic proximity Read ↗

Uncoupling of gene expression from copy number presents therapeutic opportunities in aneuploid cancersSemantic proximity Read ↗

Patterns of Aneuploidy and Signaling Consequences in CancerSemantic proximity Read ↗

PARP1 Suppression Drives ROS Resistance in Aneuploid Cancer CellsSemantic proximity Read ↗

Aneuploidy as a promoter and suppressor of malignant growth.Semantic proximity Read ↗

Effects of aneuploidy on gene expression: implications for cancer.Semantic proximity Read ↗

Increased RNA and Protein Degradation Is Required for Counteracting Transcriptional Burden and Proteotoxic Stress in Human Aneuploid CellsSemantic proximity Read ↗

Pan-cancer analysis of single-cell RNA sequencing data from 304 human tumors sheds light on the ‘aneuploidy paradox’Semantic proximity Read ↗

Aneuploidy as a cancer vulnerabilitySemantic proximity Read ↗

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damageSemantic proximity Read ↗

Identification of aneuploidy-related gene signature to predict survival in head and neck squamous cell carcinomasSemantic proximity Read ↗

Impact of somatic mutations and transcriptomic alterations on cancer aneuploidy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.