Article

The unfolded protein response links tumor aneuploidy to local immune dysregulation

2020-11-11

Abstract excerpt

Aneuploidy is a chromosomal abnormality associated with poor prognosis in many cancer types. Here we tested the hypothesis that the unfolded protein response (UPR) links mechanistically aneuploidy and local immune dysregulation. Using a single somatic copy-number alteration (SCNA) score inclusive of whole-chromosome, arm and focal chromosome alterations in a pan-cancer analysis of 9,375 samples in The Cancer Genom...

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Literature Corpus work: 17981661-92b8-57e7-b8a8-c522024df768
DOI: 10.1101/2020.11.10.377358

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