Article
Impact of somatic mutations and transcriptomic alterations on cancer aneuploidy.
Biomedical research (Tokyo, Japan) - 1 Jan 2023
Hatakeyama Keiichi, Nagashima Takeshi, Ohshima Keiichi, Ohnami Sumiko, Ohnami Shumpei, Shimoda Yuji, Naruoka Akane, Maruyama Koji, Iizuka Akira, Ashizawa Tadashi, Kenmotsu Hirotsugu, Mochizuki Tohru, Urakami Kenichi, Akiyama Yasuto, Yamaguchi Ken
Abstract excerpt
Aneuploidy has been recognized as one of hallmark of tumorigenesis since the early 20th century. Recent developments in structural variation analysis in the human genome have revealed the diversity of aneuploidy in cancer. However, the effects of gene mutation and expression in tumors on aneuploidy remain poorly understood. Here, we performed whole exome analysis of over 5,000 Japanese cancer cases and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.