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Article

Role of LGI1 protein in synaptic transmission: From physiology to pathology

22 Oct 2021

Abstract excerpt

Leucine-Rich Glioma Inactivated protein 1 (LGI1) is a secreted neuronal protein highly expressed in the central nervous system and high amount are found in the hippocampus. An alteration of its function has been described in few families of patients with autosomal dominant temporal lobe epilepsy (ADLTE) or with autoimmune limbic encephalitis (LE), both characterized by epileptic seizures. Studies have shown that...

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PMID: 34695575
DOI: 10.1016/j.nbd.2021.105537

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