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Article

LGI1: from zebrafish to human epilepsy.

Progress in brain research - 1 Jan 2014

Cowell John K

Abstract excerpt

Mutations in the LGI1 gene predispose to autosomal dominant lateral temporal lobe epilepsy, a rare hereditary form with incomplete penetrance and associated with acoustic auras. LGI1 is not a structural component of an ion channel like most epilepsy-related genes, but is a secreted protein. Mutant null mice exhibit early-onset seizures, and electrophysiological analysis shows abnormal synaptic transmission. LGI1...

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Source

Identifiers

PMID: 25194489
DOI: 10.1016/B978-0-444-63326-2.00009-0

Genes

LGI1
ADAM22
ADAM23

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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LGI1: from zebrafish to human epilepsy.PMID 25194489Read ↗

Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsySemantic proximity Read ↗

LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology.Semantic proximity Read ↗

Role of LGI1 protein in synaptic transmission: From physiology to pathologySemantic proximity Read ↗

The LGI1 protein: molecular structure, physiological functions and disruption-related seizures.Semantic proximity Read ↗

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ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segmentSemantic proximity Read ↗

LGI1 downregulation increases neuronal circuit excitabilitySemantic proximity Read ↗

LGI proteins in the nervous system.Semantic proximity Read ↗

LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal developmentSemantic proximity Read ↗

Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitabilitySemantic proximity Read ↗

Autoantibodies to Epilepsy-Related LGI1 in Limbic Encephalitis Neutralize LGI1-ADAM22 Interaction and Reduce Synaptic AMPA ReceptorsSemantic proximity Read ↗

ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segmentSemantic proximity Read ↗

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