Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.

Nature communications - 18 Apr 2018

Yamagata Atsushi, Miyazaki Yuri, Yokoi Norihiko, Shigematsu Hideki, Sato Yusuke, Goto-Ito Sakurako, Maeda Asami, Goto Teppei, Sanbo Makoto, Hirabayashi Masumi, Shirouzu Mikako, Fukata Yuko, Fukata Masaki, Fukai Shuya

Abstract excerpt

Epilepsy is a common brain disorder throughout history. Epilepsy-related ligand-receptor complex, LGI1-ADAM22, regulates synaptic transmission and has emerged as a determinant of brain excitability, as their mutations and acquired LGI1 autoantibodies cause epileptic disorders in human. Here, we report the crystal structure of human LGI1-ADAM22 complex, revealing a 2:2 heterotetrameric assembly. The hydrophobic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to Brain Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cryoelectron Microscopy

Share to Dimerization

Share to Epilepsy

Share to Protein Domains

Share to Synapses

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 29670100
DOI: 10.1038/s41467-018-03947-w
PMCID: PMC5906670

Genes

LGI1
ADAM22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.PMID 29670100Read ↗

Role of LGI1 protein in synaptic transmission: From physiology to pathologySemantic proximity Read ↗

The LGI1-ADAM22 protein complex in synaptic transmission and synaptic disorders.Semantic proximity Read ↗

Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsySemantic proximity Read ↗

Autoantibodies to Epilepsy-Related LGI1 in Limbic Encephalitis Neutralize LGI1-ADAM22 Interaction and Reduce Synaptic AMPA ReceptorsSemantic proximity Read ↗

The LGI1 protein: molecular structure, physiological functions and disruption-related seizures.Semantic proximity Read ↗

LGI proteins in the nervous system.Semantic proximity Read ↗

Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 ReceptorsSemantic proximity Read ↗

LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology.Semantic proximity Read ↗

LGI1: from zebrafish to human epilepsy.Semantic proximity Read ↗

14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice.Semantic proximity Read ↗

Gene-Burden Meta-Analysis of 748,879 Individuals Identifies LGI1-ADAM23 Protein Complex Association with EpilepsySemantic proximity Read ↗

ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.