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Article

The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1.

Neuron - 2 Mar 2006

Schulte Uwe, Thumfart Jörg-Oliver, Klöcker Nikolaj, Sailer Claudia A, Bildl Wolfgang, Biniossek Martin, Dehn Doris, Deller Thomas, Eble Silke, Abbass Karen, Wangler Tanja, Knaus Hans-Günther, Fakler Bernd

Abstract excerpt

The voltage-gated potassium (Kv) channel subunit Kv1.1 is a major constituent of presynaptic A-type channels that modulate synaptic transmission in CNS neurons. Here, we show that Kv1.1-containing channels are complexed with Lgi1, the functionally unassigned product of the leucine-rich glioma inactivated gene 1 (LGI1), which is causative for an autosomal dominant form of lateral temporal lobe epilepsy (ADLTE). In...

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Source

Identifiers

PMID: 16504945
DOI: 10.1016/j.neuron.2006.01.033

Genes

LGI1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1.PMID 16504945Read ↗

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