Article

LGI1 autoantibodies enhance synaptic transmission by presynaptic K <sub>v</sub> 1 loss and increased action potential broadening

2023-10-06

Abstract excerpt

<h4>Background and Objectives</h4> Autoantibodies against the neuronally secreted protein leucine-rich glioma inactivated 1 (LGI1) cause the most common subtype of autoimmune limbic encephalitis associated with seizures and memory deficits. LGI1 and its receptor ADAM22 are part of a transsynaptic protein complex that includes several proteins involved in presynaptic neurotransmitter release and postsynaptic gluta...

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Literature Corpus work: ce18b032-2d7f-5e6e-9168-dff4b0199ab0
DOI: 10.1101/2023.10.04.560631

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