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Article

LGI1 acts presynaptically to regulate excitatory synaptic transmission during early postnatal development

16 Feb 2016

Abstract excerpt

The secreted leucine-rich glioma inactivated 1 (LGI1) protein is an important actor for human seizures of both genetic and autoimmune etiology: mutations in LGI1 cause inherited temporal lobe epilepsy, while LGI1 is involved in antibody-mediated encephalitis. Remarkably, Lgi1-deficient (Lgi1(-/-)) mice recapitulate the epileptic disorder and display early-onset spontaneous seizures. To understand how...

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PMID: 26878798
DOI: 10.1038/srep21769

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