Article

LGI1 downregulation increases neuronal circuit excitability

2019-12-18

Abstract excerpt

LGI1 (Leucine-Rich Glioma-Inactivated 1) is a secreted trans-synaptic protein that interacts presynaptically with Kv1.1 potassium channels and ADAM23, and postsynaptically, influencing AMPA receptors through a direct link with the ADAM22 cell adhesion protein. Haploinsufficiency of LGI1 or autoantibodies directed against LGI1 are associated with human epilepsy, generating the hypothesis that a subacute reduction o...

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Literature Corpus work: 6487b219-4560-5f1b-a7f1-612639619381
DOI: 10.1101/2019.12.17.879833

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