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Article

The LGI1 protein: molecular structure, physiological functions and disruption-related seizures.

Cellular and molecular life sciences : CMLS - 30 Dec 2021

Baudin Paul, Cousyn Louis, Navarro Vincent

Abstract excerpt

Leucine-rich, glioma inactivated 1 (LGI1) is a secreted glycoprotein, mainly expressed in the brain, and involved in central nervous system development and physiology. Mutations of LGI1 have been linked to autosomal dominant lateral temporal lobe epilepsy (ADLTE). Recently auto-antibodies against LGI1 have been described as the basis for an autoimmune encephalitis, associated with specific motor and limbic...

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Identifiers

PMID: 34967933
DOI: 10.1007/s00018-021-04088-y
PMCID: PMC11072701

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