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Article

LGI proteins in the nervous system.

ASN neuro - 25 Jun 2013

Kegel Linde, Aunin Eerik, Meijer Dies, Bermingham John R

Abstract excerpt

The development and function of the vertebrate nervous system depend on specific interactions between different cell types. Two examples of such interactions are synaptic transmission and myelination. LGI1-4 (leucine-rich glioma inactivated proteins) play important roles in these processes. They are secreted proteins consisting of an LRR (leucine-rich repeat) domain and a so-called epilepsy-associated or EPTP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23713523
DOI: 10.1042/AN20120095
PMCID: PMC3691968

Genes

LGI1
ADAM22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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LGI proteins in the nervous system.PMID 23713523Read ↗

Role of LGI1 protein in synaptic transmission: From physiology to pathologySemantic proximity Read ↗

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Leucine-rich glioma inactivated 1 (Lgi1), an epilepsy-related secreted protein, has a nuclear localization signal and localizes to both the cytoplasm and the nucleus of the caudal ganglionic eminence neurons.Semantic proximity Read ↗

Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsySemantic proximity Read ↗

The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine‐rich repeat proteinsSemantic proximity Read ↗

Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.Semantic proximity Read ↗

LGI1: from zebrafish to human epilepsy.Semantic proximity Read ↗

Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy.Semantic proximity Read ↗

Autoantibodies to Epilepsy-Related LGI1 in Limbic Encephalitis Neutralize LGI1-ADAM22 Interaction and Reduce Synaptic AMPA ReceptorsSemantic proximity Read ↗

Autosomal dominant lateral temporal epilepsy in a family exhibiting a rare heterozygous mutation and deletion in the leucine-rich glioma inactivated 1 gene.Semantic proximity Read ↗

Similarity of molecular phenotype between known epilepsy gene LGI1 and disease candidate gene LGI2.Semantic proximity Read ↗

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