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Article

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

25 Oct 2021

Abstract excerpt

In an effort to identify novel drugs targeting fusion-oncogene-induced acute myeloid leukemia (AML), we performed high-resolution proteomic analysis. In AML1-ETO (AE)-driven AML, we uncovered a deregulation of phospholipase C (PLC) signaling. We identified PLCgamma 1 (PLCG1) as a specific target of the AE fusion protein that is induced after AE binding to intergenic regulatory DNA elements. Genetic inactivation...

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PMID: 34695195
DOI: 10.1182/blood.2021012778

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