Article

A critical role for PLCG1 in RAS activation by BCR-ABL1 and FLT3-ITD

2023-04-10

Abstract excerpt

Myeloid leukemias are frequently associated with pathologically activating mutations in tyrosine kinases [BCR-ABL1 in chronic myeloid leukemia (CML); FLT3 juxtamembrane internal tandem duplication (ITD) mutations, FLT3 and KIT activation loop mutations in acute myeloid leukemia (AML)]. Mutations in these kinases activate RAS, which initiates multiple downstream signaling pathways that regulate cell proliferation,...

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Literature Corpus work: 93496518-0add-534a-a24d-e791ffe639d3
DOI: 10.1101/2023.04.07.536070

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