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A Proteomics and Transcriptomics Approach to Identify Leukemic Stem Cell (LSC) Markers

11 Dec 2012

Abstract excerpt

Interactions between hematopoietic stem cells and their niche are mediated by proteins within the plasma membrane (PM) and changes in these interactions might alter hematopoietic stem cell fate and ultimately result in acute myeloid leukemia (AML). Here, using nano-LC/MS/MS, we set out to analyze the PM profile of two leukemia patient samples. We identified 867 and 610 unique CD34(+) PM (-associated) proteins in...

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PMID: 23233446
DOI: 10.1074/mcp.m112.021931

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